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Unfortunately, even over-the-counter NSAIDs like ibuprofen can cause kidney damage, especially when used in high doses or over long periods

Klemm, D

Blood 55(2):282-93, 1980

2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

Even excessive chewing (like frequent gum chewing) could contribute to symptoms of TMJ disorder

We hope that this table guides you in making an appropriate clinical decision the next time a patient presents with a history of sulfonamide allergy, and that this alleviates the fear of providing efficacious medications just because the patient has a sulfa allergy